Format

Send to

Choose Destination
See comment in PubMed Commons below
Sci Rep. 2013;3:1008. doi: 10.1038/srep01008. Epub 2013 Jan 7.

Anti-folate combination therapies and their effect on the development of drug resistance in Plasmodium vivax.

Author information

1
Department of Pathogen Biology, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China.

Abstract

Can we predict the rise and spread of resistance to multi-drug therapy in a more predictable manner? We raise this question after analyzing over 500 Plasmodium vivax isolates collected from different, geographically isolated regions of China for sequence variation in and around the dhfr and dhps genes. We find: that resistance lineages have arisen at least once in each region; that there appears to have been little movement of parasite populations between these areas; and that highly resistant parasites contain dhfr and dhps alleles that are in linkage disequilibrium. We show a direct relationship between this linkage disequilibrium and a parasite's fitness in the absence of drug pressure. Such fitness would increase the spread of drug resistant phenotypes and is thus a selectable trait. These conclusions raise questions about the appropriate use of some other drug combinations to prevent and treat infection.

PMID:
23301149
PMCID:
PMC3538286
DOI:
10.1038/srep01008
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center