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PLoS One. 2012;7(12):e53114. doi: 10.1371/journal.pone.0053114. Epub 2012 Dec 31.

Behavioral abnormalities observed in Zfhx2-deficient mice.

Author information

1
Division of Brain Biology, National Institute for Basic Biology, Okazaki, Japan.

Abstract

Zfhx2 (also known as zfh-5) encodes a transcription factor containing three homeobox domains and 18 Zn-finger motifs. We have reported that Zfhx2 mRNA is expressed mainly in differentiating neurons in the mouse brain and its expression level is negatively regulated by the antisense transcripts of Zfhx2. Although the expression profile of Zfhx2 suggests that ZFHX2 might have a role in a particular step of neuronal differentiation, the specific function of the gene has not been determined. We generated a Zfhx2-deficient mouse line and performed a comprehensive battery of behavioral tests to elucidate the function of ZFHX2. Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype. These behavioral phenotypes suggest that ZFHX2 might play roles in controlling emotional aspects through the function of monoaminergic neurons where ZFHX2 is expressed. Moreover, considering their phenotypes, the Zfhx2-deficient mice may provide a novel model of human psychiatric disorders.

PMID:
23300874
PMCID:
PMC3534046
DOI:
10.1371/journal.pone.0053114
[Indexed for MEDLINE]
Free PMC Article

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