Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS Comput Biol. 2013;9(1):e1002853. doi: 10.1371/journal.pcbi.1002853. Epub 2013 Jan 3.

Identification of a functional connectome for long-term fear memory in mice.

Author information

  • 1Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Canada.

Abstract

Long-term memories are thought to depend upon the coordinated activation of a broad network of cortical and subcortical brain regions. However, the distributed nature of this representation has made it challenging to define the neural elements of the memory trace, and lesion and electrophysiological approaches provide only a narrow window into what is appreciated a much more global network. Here we used a global mapping approach to identify networks of brain regions activated following recall of long-term fear memories in mice. Analysis of Fos expression across 84 brain regions allowed us to identify regions that were co-active following memory recall. These analyses revealed that the functional organization of long-term fear memories depends on memory age and is altered in mutant mice that exhibit premature forgetting. Most importantly, these analyses indicate that long-term memory recall engages a network that has a distinct thalamic-hippocampal-cortical signature. This network is concurrently integrated and segregated and therefore has small-world properties, and contains hub-like regions in the prefrontal cortex and thalamus that may play privileged roles in memory expression.

PMID:
23300432
PMCID:
PMC3536620
DOI:
10.1371/journal.pcbi.1002853
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center