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Curr Top Behav Neurosci. 2013;14:223-42. doi: 10.1007/7854_2012_236.

What can fear and reward learning teach us about depression?

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1
Mt. Sinai School of Medicine, New York, NY, US.

Abstract

The precise neural substrates of major depressive disorder (MDD) remain elusive, and FDA-approved antidepressants fail at least one-third of treatment-seeking patients. It is imperative, therefore, to identify novel research strategies to tackle the factors impeding progress. In this chapter we propose that the knowledge derived from computational investigations of associative learning might offer new insights into the neurobiology of MDD.

PMID:
23299804
DOI:
10.1007/7854_2012_236
[Indexed for MEDLINE]
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