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J Invest Dermatol. 2013 Jan;133(1):9-11. doi: 10.1038/jid.2012.411.

TGFβ1, an epidermal controller of skin dendritic cell homeostasis.

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1
Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Abstract

Transforming growth factor-β1 (TGFβ1) is generally regarded as an anti-inflammatory cytokine. However, previous studies suggest that TGFβ1 can promote immune responses under certain conditions. In this issue, Mohammed et al. report that epidermal keratinocyte-derived TGFβ1 alone can alter homeostasis of multiple cutaneous dendritic cell (DC) subsets, which may enhance skin inflammation. These findings may provide a better understanding of the pathogenesis of inflammatory skin disorders such as psoriasis, although how keratinocyte-derived TGFβ1 regulates cutaneous DCs under physiological and inflammatory conditions should be further addressed.

PMID:
23299448
DOI:
10.1038/jid.2012.411
[Indexed for MEDLINE]
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