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Trends Endocrinol Metab. 2013 May;24(5):229-37. doi: 10.1016/j.tem.2012.12.002. Epub 2013 Jan 5.

Aging signaling pathways and circadian clock-dependent metabolic derangements.

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1
Institute for Research in Biomedicine (IRB Barcelona), 08028 Barcelona, Spain.

Abstract

The circadian clock machinery orchestrates organism metabolism to ensure that development, survival, and reproduction are attuned to diurnal environmental variations. For unknown reasons, there is a decline in circadian rhythms with age, concomitant with declines in the overall metabolic tissue homeostasis and changes in the feeding behavior of aged organisms. This disruption of the relationship between the clock and the nutrient-sensing networks might underlie age-related diseases; overall, greater knowledge of the molecular mediators of and variations in clock networks during lifespan may shed light on the aging process and how it may be delayed. In this review we address the complex links between the circadian clock, metabolic (dys)functions, and aging in different model organisms.

PMID:
23299029
PMCID:
PMC3624052
DOI:
10.1016/j.tem.2012.12.002
[Indexed for MEDLINE]
Free PMC Article
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