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Colloids Surf B Biointerfaces. 2013 Apr 1;104:27-31. doi: 10.1016/j.colsurfb.2012.11.014. Epub 2012 Dec 6.

New method for density determination of nanoparticles using a CPS disc centrifuge™.

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Novartis Vaccines and Diagnostics GmbH, Emil-von-Behring-Strasse 76, 35041 Marburg, Germany.


A model has been developed for the determination of the correct absolute size of nanoparticles using a disc centrifuge; the method does not require externally measured or literature derived particle densities. The principle of this method is the altered settling velocity of particles in fluids with different viscosities and/or densities, with the use of a linear regression analysis for the calculation of particle densities. This allows a fast particle density determination with at least two measurements using a disc centrifuge and a small subset of easily measurable parameters. Furthermore, correctness of the model is evaluated using viruses and nonbiological particles of known densities.

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