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Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1488-93. doi: 10.1073/pnas.1221398110. Epub 2013 Jan 7.

Structural uniformity of neocortex, revisited.

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1
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. nikoosh@salk.edu

Abstract

The number of neurons under a square millimeter of cortical surface has been reported to be the same across five cortical areas and five species [Rockel et al. (1980) Brain 103(2):221-244] despite differences in cortical thickness between the areas. Although the accuracy of this result has been the subject of sharp debate since its publication approximately 30 y ago, the experiments of Rockel et al. have never been directly replicated with modern stereological methods. We have replicated these experiments and confirm the accuracy of the original report. In addition, we have observed that the number of glial cells under a square millimeter of cortical surface depends on cortical thickness, but not on cortical area or species.

PMID:
23297199
PMCID:
PMC3557031
DOI:
10.1073/pnas.1221398110
[Indexed for MEDLINE]
Free PMC Article
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