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Adv Healthc Mater. 2013 Jun;2(6):822-7. doi: 10.1002/adhm.201200385. Epub 2013 Jan 7.

A polymer-(tandem drugs) conjugate for enhanced cancer treatment.

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1
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

Abstract

A novel strategy for combination chemotherapy (platinum and demethylcantharidin) via a polymer-(tandem drugs) conjugate for enhanced cancer treatment is demonstrated. Cisplatin can be released inside cell by reduction to attack DNA, while DMC will be hydrolyzed subsequently to block DNA-damage-induced defense mechanisms by serine/threonine phosphatase PP2A inhibition. Synergistic effect of the polymer-(tandem drugs) conjugate causes complete suppression of H22 liver tumor xenografts without recurrence.

PMID:
23296686
DOI:
10.1002/adhm.201200385
[Indexed for MEDLINE]
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