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Methods Mol Biol. 2013;965:421-37. doi: 10.1007/978-1-62703-239-1_28.

Assessing chronological aging in bacteria.

Author information

1
Department of Biological Sciences, Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA.

Abstract

Bacteria, which are often considered as avid reproductive organisms under constant selective pressure to utilize available nutrients to proliferate, might seem an inappropriate model to study aging. However, environmental conditions are rarely supporting the exponential growth that is most often studied in laboratories. In the wild, Escherichia coli inhabits environments of relative nutritional paucity. Not surprisingly, under such circumstances, members of an E. coli population age and progressively lose the ability to reproduce, even when environmental conditions provide such an opportunity. Here, we review the methods to study chronological aging in bacteria and some of the mechanisms that may contribute to their age-dependent loss of viability.

PMID:
23296675
PMCID:
PMC4077615
DOI:
10.1007/978-1-62703-239-1_28
[Indexed for MEDLINE]
Free PMC Article

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