Format

Send to

Choose Destination
See comment in PubMed Commons below
Toxicology. 2013 May 10;307:17-23. doi: 10.1016/j.tox.2012.12.016. Epub 2013 Jan 4.

The interplay between environmental and genetic factors in Parkinson's disease susceptibility: the evidence for pesticides.

Author information

1
Department of Neurology, Faculty of Medicine, University of Thessaly, Greece.

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra. Several genetic and environmental factors have been implicated in the pathogenesis of PD. Single risk factors are likely to exert relatively minor effects, whereas their interaction may prove to be sufficient to cause PD. In the present review we summarize current knowledge from human genetic association studies regarding the interaction between gene polymorphisms and pesticide exposure in the risk of PD. A number of genetic association studies have investigated joint effects between genes and pesticides on PD risk. They have provided some evidence that genetic susceptibility either in metabolism, elimination and transport of pesticides or in the extent of mitochondrial dysfunction, oxidative stress and neuronal loss may predispose individuals to PD if they have been exposed to pesticides. These findings confirm the importance of considering pesticide-gene interactions in future studies in order to gain a better understanding of the pathogenic mechanisms of PD.

PMID:
23295711
DOI:
10.1016/j.tox.2012.12.016
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center