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Chem Commun (Camb). 2013 Feb 14;49(13):1303-5. doi: 10.1039/c2cc38570h. Epub 2013 Jan 8.

A two-photon fluorescent probe for amyloid-β plaques in living mice.

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1
Division of Energy Systems Research, Ajou University, Suwon, 443-749, Korea.

Abstract

We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.

PMID:
23295364
DOI:
10.1039/c2cc38570h
[Indexed for MEDLINE]
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