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EMBO Rep. 2013 Mar 1;14(3):252-60. doi: 10.1038/embor.2012.218. Epub 2013 Jan 8.

A single internal telomere tract ensures meiotic spindle formation.

Author information

1
Telomere Biology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. k.tomita@ucl.ac.uk

Abstract

Contact between telomeres and the fission yeast spindle pole body during meiotic prophase is crucial for subsequent spindle assembly, but the feature of telomeres that confers their ability to promote spindle formation remains mysterious. Here we show that while strains harbouring circular chromosomes devoid of telomere repeat tracts undergo aberrant meiosis with defective spindles, the insertion of a single internal telomere repeat stretch rescues the spindle defects. Moreover, the telomeric overhang-binding protein Pot1 is dispensable for rescue of spindle formation. Hence, an inherent feature of the double-strand telomeric region endows telomeres with the capacity to promote spindle formation.

PMID:
23295325
PMCID:
PMC3589085
DOI:
10.1038/embor.2012.218
[Indexed for MEDLINE]
Free PMC Article

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