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Curr Opin Struct Biol. 2013 Apr;23(2):198-205. doi: 10.1016/j.sbi.2012.12.003. Epub 2013 Jan 5.

Low-resolution structural modeling of protein interactome.

Author information

1
Center for Bioinformatics, The University of Kansas, Lawrence, KS 66047, USA. vakser@ku.edu

Abstract

Structural characterization of protein-protein interactions across the broad spectrum of scales is key to our understanding of life at the molecular level. Low-resolution approach to protein interactions is needed for modeling large interaction networks, given the significant level of uncertainties in large biomolecular systems and the high-throughput nature of the task. Since only a fraction of protein structures in interactome are determined experimentally, protein docking approaches are increasingly focusing on modeled proteins. Current rapid advancement of template-based modeling of protein-protein complexes is following a long standing trend in structure prediction of individual proteins. Protein-protein templates are already available for almost all interactions of structurally characterized proteins, and about one third of such templates are likely correct.

PMID:
23294579
PMCID:
PMC3676717
DOI:
10.1016/j.sbi.2012.12.003
[Indexed for MEDLINE]
Free PMC Article
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