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Curr Opin Neurobiol. 2013 Apr;23(2):162-71. doi: 10.1016/j.conb.2012.11.015. Epub 2013 Jan 4.

Network attributes for segregation and integration in the human brain.

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Indiana University, Department of Psychological and Brain Sciences, Bloomington, IN 47405, United States.


Network studies of large-scale brain connectivity have begun to reveal attributes that promote the segregation and integration of neural information: communities and hubs. Network communities are sets of regions that are strongly interconnected among each other while connections between members of different communities are less dense. The clustered connectivity of network communities supports functional segregation and specialization. Network hubs link communities to one another and ensure efficient communication and information integration. This review surveys a number of recent reports on network communities and hubs, and their role in integrative processes. An emerging focus is the shifting balance between segregation and integration over time, which manifest in continuously changing patterns of functional interactions between regions, circuits and systems.

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