Format

Send to

Choose Destination
See comment in PubMed Commons below
Epilepsia. 2013 Mar;54(3):461-70. doi: 10.1111/epi.12057. Epub 2013 Jan 7.

Reduced default mode network connectivity in treatment-resistant idiopathic generalized epilepsy.

Author information

1
Neuroscience Graduate Program, University of Cincinnati, Cincinnati, Ohio, USA. benjamin@benkay.net

Abstract

PURPOSE:

Idiopathic generalized epilepsy (IGE) resistant to treatment is common, but its neuronal correlates are not entirely understood. Therefore, the aim of this study was to examine resting-state default mode network (DMN) functional connectivity in patients with treatment-resistant IGE.

METHODS:

Treatment resistance was defined as continuing seizures despite an adequate dose of valproic acid (valproate, VPA). Data from 60 epilepsy patients and 38 healthy controls who underwent simultaneous electroencephalography (EEG) and resting-state functional magnetic resonance imaging (fMRI) were included (EEG/fMRI). Independent component analysis (ICA) and dual regression were used to quantify DMN connectivity. Confirmatory analysis using seed-based voxel correlation was performed.

KEY FINDINGS:

There was a significant reduction of DMN connectivity in patients with treatment-resistant epilepsy when compared to patients who were treatment responsive and healthy controls. Connectivity was negatively correlated with duration of epilepsy.

SIGNIFICANCE:

Our findings in this large sample of patients with IGE indicate the presence of reduced DMN connectivity in IGE and show that connectivity is further reduced in treatment-resistant epilepsy. DMN connectivity may be useful as a biomarker for treatment resistance.

PMID:
23293853
PMCID:
PMC3593969
DOI:
10.1111/epi.12057
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center