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Expert Opin Ther Targets. 2013 Mar;17(3):281-91. doi: 10.1517/14728222.2013.740461. Epub 2013 Jan 8.

Cathepsin B as a cancer target.

Author information

1
University of Illinois College of Medicine at Peoria, Department of Cancer Biology and Pharmacology and Neurosurgery, Peoria, IL, USA.

Abstract

INTRODUCTION:

Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans. Numerous studies have shown that abnormal regulation of cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers. Cathepsin B is normally associated with the lysosomes involved in autophagy and immune response, but its aberrant expression has been shown to lead to cancers.

AREAS COVERED:

This review highlights the oncogenic role of cathepsin B, discusses the regulation of cathepsin B in light of oncogenesis, discusses the role of cathepsin B as a signaling molecule, and highlights the therapeutic potential of targeting cathepsin B.

EXPERT OPINION:

Targeting cathepsin B alone does not appear to abolish tumor growth, and this is probably because cathepsin B appears to have diverse functions and influence numerous pathways. It is not clear whether global suppression of cathepsin B activity or expression would produce unintended effects or cause the activation or suppression of unwanted pathways. A localized approach for targeting the expression of cathepsin B would be more relevant. Moreover, a combination of targeting cathepsin B with other relevant oncogenic molecules has significant therapeutic potential.

PMID:
23293836
PMCID:
PMC3587140
DOI:
10.1517/14728222.2013.740461
[Indexed for MEDLINE]
Free PMC Article

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