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Contemp Clin Dent. 2012 Jul;3(3):288-93. doi: 10.4103/0976-237X.103620.

Evaluation of minimum inhibitory and minimum bactericidal concentration of nano-silver base inorganic anti-microbial agent (Novaron(®)) against streptococcus mutans.

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1
Department of Pedodontics and Preventive Dentistry, Kanti Devi Denta College and Hospital, Mathura, Uttar Pradesh, India.

Abstract

OBJECTIVE:

We attempted to find the possibility of determining the minimum inhibitory concentration and minimum bactericidal concentration needed for nano-silver base inorganic anti-microbial agent (Novaron(®) AG 300, AG 1100) against Streptococcus mutans in vitro using broth dilution assay.

MATERIALS AND METHODS:

An ampoule of freeze-dried S. mutans NCTC reference strain was revived, and the colony-forming units (CFU) were calculated. The MIC and MBC was determined by broth dilution assay using different concentrations of Novaron(®) AG 300 and Novaron(®) AG 1100 against 1 × 10(5) CFU/ml of S. mutans.

RESULTS:

The MIC and MBC of Novaron(®) AG 300 and Novaron(®) AG 1100 against S. mutans were found to be 40 μg/ml.

CONCLUSIONS:

Novaron(®) has anti-bacterial effect against S. mutans. Further studies are needed to explore the applicability of these silver-supported anti- microbial agents in clinical dentistry.

KEYWORDS:

Broth dilution assay; MBC; MIC; S. Mutans; novaron®; silver-supported anti-microbial agent

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