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Toxicol Int. 2012 Sep;19(3):241-4. doi: 10.4103/0971-6580.103656.

A study on the toxic effects of Doxorubicin on the histology of certain organs.

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1
Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad, Andhra Pradesh, India.

Abstract

In the present study, effect of doxorubicin at 2 mg/kg b.wt. (i/p), alone, once in a wk for 4 wks and in combination with vitamin E at 250 and 500 mg/kg b.wt., orally, daily for 4 wks was evaluated on histological alterations, if any, on heart, liver, kidney, and testes of rats. Doxorubicin alone treated group showed marked congestion and degenerative changes in heart, kidney, liver, and testis. Treatment with vitamin E showed marked improvement in all the degenerative changes, though more protection was observed with the dose of 500 mg/kg.

KEYWORDS:

Doxorubicin; histopathology; vitamin-E

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