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Biosci Biotechnol Biochem. 2013;77(1):194-7. Epub 2013 Jan 7.

Improved high-fat diet-induced glucose intolerance by an oral administration of phytosphingosine.

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1
Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Sciences, Hokkaido University, Sapporo, Japan.

Abstract

We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in cells. PPARγ is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes.

PMID:
23291756
DOI:
10.1271/bbb.120644
[Indexed for MEDLINE]
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