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Nat Methods. 2013 Feb;10(2):128-32. doi: 10.1038/nmeth.2330. Epub 2013 Jan 6.

Identifying RNA editing sites using RNA sequencing data alone.

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1
Department of Genetics, Stanford University, Stanford, California, USA.

Abstract

We show that RNA editing sites can be called with high confidence using RNA sequencing data from multiple samples across either individuals or species, without the need for matched genomic DNA sequence. We identified many previously unidentified editing sites in both humans and Drosophila; our results nearly double the known number of human protein recoding events. We also found that human genes harboring conserved editing sites within Alu repeats are enriched for neuronal functions.

PMID:
23291724
PMCID:
PMC3676881
DOI:
10.1038/nmeth.2330
[Indexed for MEDLINE]
Free PMC Article
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