Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Parasitol. 2013 Mar;43(3-4):301-10. doi: 10.1016/j.ijpara.2012.11.011. Epub 2013 Jan 3.

Immunomodulation by helminth parasites: defining mechanisms and mediators.

Author information

  • 1Institute of Immunology and Infection Research, University of Edinburgh, UK. hank.mcsorley@gmail.com

Abstract

Epidemiological and interventional human studies, as well as experiments in animal models, strongly indicate that helminth parasitic infections can confer protection from immune dysregulatory diseases such as allergy, autoimmunity and colitis. Here, we review the immunological pathways that helminths exploit to downregulate immune responses, both against bystander specificities such as allergens and against antigens from the parasites themselves. In particular, we focus on a highly informative laboratory system, the mouse intestinal nematode, Heligmosomoides polygyrus, as a tractable model of host-parasite interaction at the cellular and molecular levels. Analysis of the molecules released in vitro (as excretory-secretory products) and their cellular targets is identifying individual parasite molecules and gene families implicated in immunomodulation, and which hold potential for future human therapy of immunopathological conditions.

PMID:
23291463
DOI:
10.1016/j.ijpara.2012.11.011
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center