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Am J Kidney Dis. 2013 May;61(5):701-9. doi: 10.1053/j.ajkd.2012.11.034. Epub 2013 Jan 4.

Association of cardiac troponin T with left ventricular structure and function in CKD.

Collaborators (184)

Feldman HI, Landis JR, Anderson AH, Ballard S, Chai B, Dember LM, Dickson J, Durborow M, Girard C, Glenn M, Helker ES, Kanetsky PA, Kasner S, Kimmel SE, Mazurick C, Messe SR, Nessel L, Pan Q, Robinson N, Roy J, Tao KK, Teal VL, Whitehead K, Xie D, Yang WP, Zhang X, Townsend RR, Cohen D, Cuevas MM, Duckworth MJ, Ford V, Huan Y, Kallem RR, Leshner J, McDowell S, Mohler ER 3rd, Seamon WM, Sheridan A, Strelsin J, Teff K, Appel LJ, Anderson C, Chan T, Chang A, Charleston J, Harrison T, Jaar B, Martin C, Miller EP, Ngoh P, Sozio S, Turban S, Fink J, Diamantidis C, Fink W, Lucas L, Page T, Parsa A, Scism B, Seliger S, Weir M, Rahman M, Dobre MA, Clark K, Corrigan V, Kisin G, Kanthety R, Strauss L, Wright JT Jr, Schelling J, Horwitz EJ, Guillon L, O'Brien A, O'Malley N, Prakash S, Sedor JR, Shella MA, Slaven A, Theurer J, Thornton JD, Navaneethan SD, Schreiber MJ, Taliercio J, Coleman M, Hopkins K, Danziger-Isakov L, Markle T, Ramos M, Russo A, Slattery S, Stelmach K, Stephens V, Ojo A, Sundaram B, Briesmiester J, Cornish-Zirker D, Hill N, Jamerson K, Saran R, Welliver B, Wilson J, Young E, Wright J, Steigerwalt SP, Bellovich K, DeLuca J, Makos G, Walls K, Flack JM, Sondheimer J, Mahn J, Maysura M, Migdal S, Mohanty MJ, Muzyk C, Zhuang Y, Lash JP, Brecklin C, Carmona E, Cohan J, Fischer M, Frydrych A, Lopez A, Lora C, Martinez M, Mercado A, Moreno B, Meslar P, Ricardo A, He J, Alper B, Batuman V, Bazzano LA, Borja B, Chen J, Cooke C, Delafontaine P, DeSalvo KB, Dolan J, Hamm L, Lustigova E, Mahone E, Sansing L, Starcke C, Go AS, Choi A, Dorin P, Jensvold NG, Lo JC, Metzger L, Nasol EF, Ordonez JD, Perloff R, Sasso N, Thompson D, Yang J, Hsu CY, Chertow GM, Kusek JW, Narva AS, Fried L, Gilbertson DT, McClellan W, McCullough PA, Nathan D, O'Hare AM, Palevsky PM, Rich SS, Stokes JB, Wei GS, Wilson PW, Donovan M, Master S, Mifflin T, Morrell L, Hall P, Rolin H, Saunders S, Budoff M, Dailing C, Soliman EZ, Zhang ZM, St John Sutton M, Keane MG.

Author information

1
University of California, San Francisco, CA, USA. rakesh.mishra@ucsf.edu

Abstract

BACKGROUND:

Serum cardiac troponin T (cTnT) is associated with increased risk of heart failure and cardiovascular death in several population settings. We evaluated associations of cTnT levels with cardiac structural and functional abnormalities in a cohort of patients with chronic kidney disease (CKD) without heart failure.

STUDY DESIGN:

Cross-sectional.

SETTING & PARTICIPANTS:

Chronic Renal Insufficiency Cohort (CRIC; N=3,243).

PREDICTOR:

The primary predictor was cTnT level. Secondary predictors included demographic and clinical characteristics, hemoglobin level, high-sensitivity C-reactive protein level, and estimated glomerular filtration rate using cystatin C.

OUTCOMES:

Echocardiography was used to determine left ventricular (LV) mass and LV systolic and diastolic function.

MEASUREMENTS:

Circulating cTnT was measured in stored sera using the highly sensitive assay. Logistic and linear regression models were used to examine associations of cTnT level with each echocardiographic outcome.

RESULTS:

cTnT was detectable in 2,735 (84%) persons; median level was 13.3 (IQR, 7.7-23.8) pg/mL. Compared with undetectable cTnT (<3.0 pg/mL), the highest quartile (23.9-738.7 pg/mL) was approximately 2 times as likely to have LV hypertrophy (OR, 2.43; 95% CI, 1.44-4.09) in the fully adjusted model. cTnT level had a more modest association with LV systolic dysfunction; as a log-linear variable, a significant association was present in the fully adjusted model (OR of 1.4 [95% CI, 1.2-1.7] per 1-log unit; P < 0.001). There was no significant independent association between cTnT level and LV diastolic dysfunction. When evaluated as a screening test, cTnT level functioned only modestly for LV hypertrophy and concentric hypertrophy detection (area under the curve, 0.64 for both), with weaker areas under the curve for the other outcomes.

LIMITATIONS:

The presence of coronary artery disease was not formally assessed using either noninvasive or angiographic techniques in this study.

CONCLUSIONS:

In this large CKD cohort without heart failure, detectable cTnT had a strong association with LV hypertrophy, a more modest association with LV systolic dysfunction, and no association with diastolic dysfunction. These findings indicate that circulating cTnT levels in patients with CKD are predominantly an indicator of pathologic LV hypertrophy.

PMID:
23291148
PMCID:
PMC3627820
DOI:
10.1053/j.ajkd.2012.11.034
[Indexed for MEDLINE]
Free PMC Article

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