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Trends Cardiovasc Med. 2013 Feb;23(2):52-8. doi: 10.1016/j.tcm.2012.08.011. Epub 2013 Jan 3.

Improving outcomes after cardiac arrest using NO inhalation.

Author information

1
Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. fichinose@partners.org

Abstract

Despite advances in cardiopulmonary resuscitation (CPR) methods including therapeutic hypothermia (TH), long-term neurological outcomes and survival after sudden cardiac arrest (CA) remains to be dismal. While nitric oxide (NO) prevents organ injury induced by ischemia and reperfusion (I/R), systemic vasodilation induced by intravenous NO-donor compounds typically precludes its use in post-CA patients in whom blood pressure is often low and unstable. Although developed as a selective pulmonary vasodilator, inhaled NO has systemic benefits in a variety of pre-clinical and clinical studies without causing potentially harmful systemic vasodilation. Breathing NO after CPR may prevent post-CA brain injury and improve long-term outcomes after CA and CPR.

PMID:
23291033
PMCID:
PMC3644182
DOI:
10.1016/j.tcm.2012.08.011
[Indexed for MEDLINE]
Free PMC Article

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