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Homeopathy. 2013 Jan;102(1):49-53. doi: 10.1016/j.homp.2012.11.001.

Effect of the oral administration homeopathic Arnica montana on mitochondrial oxidative stress.

Author information

1
Fundação Hermínio Ometto, Uniararas, Araras, SP, Brazil.

Abstract

OBJECTIVE:

To analyze the effect of homeopathic Arnica on mitochondrial oxidative stress induced by Ca(2+) plus inorganic phosphate and/or Fe(2+)-citrate-mediated lipid peroxidation through changes in oxygen consumption rates.

METHODS:

Mitochondria were isolated by differential centrifugation from the livers of adult male Wistar rats which had been treated with Arnica montana 6cH, 12cH, 30cH or succussed 30% ethanol (control) for 21 days.

RESULTS:

In the presence of antimycin-A, electron transport chain inhibitor, as evidenced by antimycin-A insensitive O(2) consumption, Arnica inhibited lipid peroxidation of mitochondrial membranes. In oxidative stress conditions, in the presence of Ca(2+) and inorganic phosphate, animals receiving Arnica 30cH had a significant decrease in mitochondrial O(2) consumption compared to control animals.

CONCLUSION:

When administrated orally, Arnica 30cH protects against hepatic mitochondrial membrane permeabilization induced by Ca(2+) and/or Fe(2+)-citrate-mediated lipid peroxidation and fragmentation of proteins due to the attack by reactive oxygen species.

PMID:
23290879
DOI:
10.1016/j.homp.2012.11.001
[Indexed for MEDLINE]

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