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Curr Opin Genet Dev. 2012 Dec;22(6):533-41. doi: 10.1016/j.gde.2012.10.005. Epub 2013 Jan 4.

Drosophila blastoderm patterning.

Author information

1
EMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation and Universitat Pompeu Fabra, Barcelona, Spain. yogi.jaeger@crg.eu

Abstract

The Drosophila blastoderm embryo is a classic model for the study of the genetics of pattern formation. In recent years, quantitative empirical approaches have been employed extensively in the study of blastoderm pattern formation. This quantitative work has enabled the development of a number of data-driven computational models. More than in other systems, these models have been experimentally validated, and have informed new empirical work. They have led to insights into the establishment of morphogen gradients, the interpretation and transduction of positional information by downstream transcriptional networks, and the mechanisms by which spatial scaling and robustness of gene expression are achieved. Here we review the latest developments in the field.

PMID:
23290311
DOI:
10.1016/j.gde.2012.10.005
[Indexed for MEDLINE]
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