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Cell Stem Cell. 2013 Jan 3;12(1):1-3. doi: 10.1016/j.stem.2012.12.005.

Metabolic makeover for HSCs.

Author information

1
The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Medicine, Hematology/Oncology Division, University of California at San Francisco, San Francisco, CA 94143, USA.

Abstract

Hematopoietic stem cells (HSCs) must at times exit quiescence to divide and produce differentiated blood cells. In this issue of Cell Stem Cell, Takubo et al. (2013) and Yu et al. (2013) show that these opposing actions require distinct metabolic programs to meet the changing energy demands of self-renewing HSCs.

PMID:
23290130
DOI:
10.1016/j.stem.2012.12.005
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