Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Neurol. 2013 Jan;48(1):48-51. doi: 10.1016/j.pediatrneurol.2012.09.003.

Pontocerebellar hypoplasia in extreme prematurity: clinical and neuroimaging findings.

Author information

First Department of Pediatrics, Aristotle University, Hippokratio General Hospital, Thessaloniki, Greece.


The involvement of the cerebellum in unfavorable outcomes of extreme prematurity is increasingly recognized. Evidence implicates both cerebellar injury and cerebellar growth failure, which, along with supratentorial lesions, aggravate motor and developmental outcomes. We describe clinical and neuroradiologic findings of 12 extremely premature patients with acquired pontocerebellar hypoplasia (mean follow-up, 4 years). Patients' neuromotor outcomes involved combined motor abnormalities (spasticity, dystonia, and ataxia), whereas 25% were ambulatory by age 4 years. All patients exhibited developmental delays of variable degrees. One patient died at age 7.5 years. The possible etiopathogenesis, presentations, sequelae, and differential diagnoses of acquired pontocerebellar hypoplasia are discussed.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center