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IEEE Trans Ultrason Ferroelectr Freq Control. 2013 Jan;60(1):46-52. doi: 10.1109/TUFFC.2013.2536.

Microbubble attenuation and destruction: are they involved in sonoporation efficiency?

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UMR Imagerie et Cerveau, Inserm U 930, Universite Francois Rabelais, Tours, France.


This technical note investigates the involvement of microbubble attenuation and destruction in sonoporation mechanisms. First, we evaluate sonoporation efficiency using Vevo Micromarker, and a comparison is made with BR14 and SonoVue microbubbles. Then, the acoustical properties of the microbubbles are measured to gain insight into the sonoporation mechanisms using a green fluorescent protein as a marker. Using glioblastoma cells, an unprecedented transfection rate of 70% is reached with Vevo Micromarker, corresponding to a 1.5-fold increase compared with the rate achieved with the other microbubbles. Moreover, attenuation and destruction were shown to be two key parameters in sonoporation efficiency.

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