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Dermatol Online J. 2012 Dec 15;18(12):24.

Disseminated superficial actinic porokeratosis.

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The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, USA.


Disseminated superficial actinic porokeratosis, which was described in 1966, is characterized by small, atrophic patches with distinctive keratin rims that occur on sun-exposed areas of the extremities, shoulders, and back. The diagnosis is based on the histopathologic finding of a cornoid lamella, absence of a granular layer, and often a thin epidermis. It is associated with exposure to ultraviolet radiation. Gene studies suggest a pathway defect in which several mutations in keratinocyte proliferation and differentiation lead to development of porokeratosis.

[Indexed for MEDLINE]

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