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A framework for quantifying node-level community structure group differences in brain connectivity networks.

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1
Electrical and Computer Engineering Department, University of Illinois at Chicago, USA. jgadel2@uic.edu

Abstract

We propose a framework for quantifying node-level community structures between groups using anatomical brain networks derived from DTI-tractography. To construct communities, we computed hierarchical binary trees by maximizing two metrics: the well-known modularity metric (Q), and a novel metric that measures the difference between inter-community and intra-community path lengths. Changes in community structures on the nodal level were assessed between generated trees and a statistical framework was developed to detect local differences between two groups of community structures. We applied this framework to a sample of 42 subjects with major depression and 47 healthy controls. Results showed that several nodes (including the bilateral precuneus, which have been linked to self-awareness) within the default mode network exhibited significant differences between groups. These findings are consistent with those reported in previous literature, suggesting a higher degree of ruminative self-reflections in depression.

PMID:
23286049
PMCID:
PMC3854964
[Indexed for MEDLINE]
Free PMC Article
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