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PLoS One. 2012;7(12):e52447. doi: 10.1371/journal.pone.0052447. Epub 2012 Dec 20.

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

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1
Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Sevilla, Spain.

Abstract

THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages.

PMID:
23285047
PMCID:
PMC3527488
DOI:
10.1371/journal.pone.0052447
[Indexed for MEDLINE]
Free PMC Article
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