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PLoS One. 2012;7(12):e51169. doi: 10.1371/journal.pone.0051169. Epub 2012 Dec 20.

The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron.

Author information

1
Department of Computer Science, University of Warwick, Coventry, West Midlands, United Kingdom. mikeforrest@hotmail.com

Abstract

In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is selected. We have constructed a realistic biophysical Purkinje cell model that can replicate these patterns. In this model, Na(+)/K(+) pump activity sets the Purkinje cell's operating mode. From rat cerebellar slices we present Purkinje whole cell recordings in the presence of ouabain, which irreversibly blocks the Na(+)/K(+) pump. The model can replicate these recordings. We propose that Na(+)/K(+) pump activity controls the intrinsic firing mode of cerbellar Purkinje cells.

PMID:
23284664
PMCID:
PMC3527461
DOI:
10.1371/journal.pone.0051169
[Indexed for MEDLINE]
Free PMC Article

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