Send to

Choose Destination
PLoS One. 2012;7(12):e51169. doi: 10.1371/journal.pone.0051169. Epub 2012 Dec 20.

The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron.

Author information

Department of Computer Science, University of Warwick, Coventry, West Midlands, United Kingdom.


In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence. The bimodal pattern consists of tonic spiking and quiescence. It is unclear how these firing patterns are generated and what determines which firing pattern is selected. We have constructed a realistic biophysical Purkinje cell model that can replicate these patterns. In this model, Na(+)/K(+) pump activity sets the Purkinje cell's operating mode. From rat cerebellar slices we present Purkinje whole cell recordings in the presence of ouabain, which irreversibly blocks the Na(+)/K(+) pump. The model can replicate these recordings. We propose that Na(+)/K(+) pump activity controls the intrinsic firing mode of cerbellar Purkinje cells.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center