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PLoS One. 2012;7(12):e46187. doi: 10.1371/journal.pone.0046187. Epub 2012 Dec 20.

UV filters, ingredients with a recognized anti-inflammatory effect.

Author information

1
Université de Nantes, Nantes Atlantique Universités, MMS, EA 2160, FR CNRS 3473, Nantes, France.

Abstract

BACKGROUND:

To explain observed differences during SPF determination using either an in vivo or in vitro method, we hypothesized on the presence of ingredients having anti-inflammatory properties.

METHODOLOGY/PRINCIPAL FINDINGS:

To research our hypothesis, we studied the 21 UV filters both available on the market and authorized by European regulations and subjected these filters to the phorbol-myristate-acetate test using mice. We then catalogued the 13 filters demonstrating a significant anti-inflammatory effect with edema inhibition percentages of more than 70%. The filters are: diethylhexyl butamido triazone (92%), benzophenone-5 and titanium dioxide (90%), benzophenone-3 (83%), octocrylène and isoamyl p-methoxycinnamate (82%), PEG-25 PABA and homosalate (80%), octyl triazone and phenylbenzimidazole sulfonic acid (78%), octyl dimethyl PABA (75%), bis-ethylhexyloxyphenol methoxyphenyl triazine and diethylamino hydroxybenzoyl hexylbenzoate (70%). These filters were tested at various concentrations, including their maximum authorized dose. We detected a dose-response relationship.

CONCLUSIONS/SIGNIFICANCE:

The anti-inflammatory effect of a sunscreen ingredient may affect the in vivo SPF value.

PMID:
23284607
PMCID:
PMC3527392
DOI:
10.1371/journal.pone.0046187
[Indexed for MEDLINE]
Free PMC Article

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