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J Am Dent Assoc. 2013 Jan;144(1):21-30.

Results from the Xylitol for Adult Caries Trial (X-ACT).

Author information

1
School of Dentistry, University of North Carolina at Chapel Hill, CB#7450, Chapel Hill, N.C. 27599-7450, USA. jim_bader@unc.edu

Abstract

BACKGROUND:

Although caries is prevalent in adults, investigators have tested few preventive therapies in adult populations. In a randomized controlled trial, the authors evaluated the effectiveness of xylitol lozenges in preventing caries in adults at elevated risk of developing caries.

METHODS:

The Xylitol for Adult Caries Trial (X-ACT) was a three-site placebo-controlled randomized trial. Participants (n = 691) aged 21 through 80 years consumed five 1.0-gram xylitol or placebo lozenges daily for 33 months. They underwent clinical examinations at baseline and at 12, 24 and 33 months.

RESULTS:

Xylitol lozenges reduced the caries increment 10 percent. This reduction, which represented less than one-third of a surface per year, was not statistically significant. There was no indication of a dose-response effect.

CONCLUSIONS:

Daily use of xylitol lozenges did not result in a statistically or clinically significant reduction in 33-month caries increment among adults at an elevated risk of developing caries.

CLINICAL IMPLICATIONS:

These results suggest that xylitol used as a supplement in adults does not reduce their caries experience significantly.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00393055.

Comment in

PMID:
23283923
PMCID:
PMC3926805
[Indexed for MEDLINE]
Free PMC Article

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