Format

Send to

Choose Destination
See comment in PubMed Commons below
Extremophiles. 2013 Mar;17(2):193-203. doi: 10.1007/s00792-012-0509-1. Epub 2013 Jan 3.

Multifunctional enzymes in archaea: promiscuity and moonlight.

Author information

1
College of Plant Sciences, Jilin University, Changchun, China. baoleijia@jlu.edu.cn

Abstract

Enzymes from many archaea colonizing extreme environments are of great interest because of their potential for various biotechnological processes and scientific value of evolution. Many enzymes from archaea have been reported to catalyze promiscuous reactions or moonlight in different functions. Here, we summarize known archaeal enzymes of both groups that include different kinds of proteins. Knowledge of their biochemical properties and three-dimensional structures has proved invaluable in understanding mechanism, application, and evolutionary implications of this manifestation. In addition, the review also summarizes the methods to unravel the extra function which almost was discovered serendipitously. The study of these amazing enzymes will provide clues to optimize protein engineering applications and how enzymes might have evolved on Earth.

PMID:
23283522
DOI:
10.1007/s00792-012-0509-1
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center