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Ocul Immunol Inflamm. 2013 Apr;21(2):148-9. doi: 10.3109/09273948.2012.737889. Epub 2013 Jan 2.

Cytomegalovirus retinitis following intravitreal triamcinolone acetonide in a patient with chronic uveitis on systemic immunosuppression.

Author information

1
Department of Ophthalmology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

Abstract

PURPOSE:

To report a case of cytomegalovirus (CMV) retinitis in an HIV-negative, iatrogenically immunosuppressed patient with chronic uveitis following intravitreal triamcinolone acetonide (IVTA).

DESIGN:

Observational case report.

METHODS:

A 56-year-old female with chronic idiopathic panuveitis on azathioprine received a single 4-mg IVTA injection for macular edema and presented after 6 months with severe retinitis.

RESULTS:

CMV was confirmed by polymerase chain reaction of vitreous fluid. The retinitis responded well to intravitreal ganciclovir, but she developed a rhegmatogenous retinal detachment and underwent vitrectomy with silicone oil tamponade.

CONCLUSIONS:

Sight-threatening CMV retinitis may develop in HIV-negative, immunosuppressed individuals after IVTA. Regular fundoscopy for up to 9 months after IVTA is recommended.

PMID:
23282087
DOI:
10.3109/09273948.2012.737889
[Indexed for MEDLINE]

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