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Mod Pathol. 2013 Jan;26 Suppl 1:S57-70. doi: 10.1038/modpathol.2012.182.

Shades of gray between large B-cell lymphomas and Hodgkin lymphomas: differential diagnosis and biological implications.

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1
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street, Boston, MA 02114, USA. nlharris@partners.org

Abstract

Hodgkin lymphomas (HLs) are neoplasms of large B cells. Two types are recognized: nodular lymphocyte predominant HL (NLPHL) and classical HL (CHL). In both types, there may be morphological and possibly biological overlap with large B-cell lymphomas (LBCLs) of non-HL types. These include nodular sclerosis CHL and primary mediastinal large B-cell lymphoma; CHL rich in lymphocytes and NLPHL; and NLPHL and T-cell/histiocyte-rich LBCL. This review covers the defining features of each of these diseases, the borderlines between them, and strategies for differential diagnosis.

PMID:
23281436
DOI:
10.1038/modpathol.2012.182
[Indexed for MEDLINE]
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