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Muscle Nerve. 2013 Feb;47(2):276-8. doi: 10.1002/mus.23692. Epub 2012 Dec 28.

Volume matters: the influence of different botulinum toxin-A dilutions for sialorrhea in amyotrophic lateral sclerosis.

Author information

1
Department of Neurology, University of Athens, Eginition Hospital, Vas. Sophias Avenue 74, 11528 Athens, Greece. granavan@yahoo.com

Erratum in

  • Muscle Nerve. 2013 Jul;48(1):155. Evangelos, Anagnostou [corrected to Anagnostou, Evangelos]; Michael, Rentzos [corrected to Rentzos, Michael]; Theodoros, Alexakis [corrected to Alexakis, Theodoros]; Vasiliki, Zouvelou [corrected to Zouvelou, Vasiliki]; Thomas, Zambelis [corrected to Zambelis, Thomas]; Ioannis, Evdokimidis [corrected to Evdokimidis, Ioannis].

Abstract

INTRODUCTION:

We aimed to determine the effect of different botulinum toxin-A (BTX-A) dilutions on the treatment efficacy and side effects for amyotrophic lateral sclerosis (ALS) related sialorrhea.

METHODS:

Ten patients were enrolled in the study. BTX-A dilution for Group A was 100 U in 1 ml of saline, whereas the dilution for Group B was 100 U in 2 ml of saline. Both groups received 20 U of BTX-A in each parotid gland, and assessments were made by means of the Drooling Impact Scale, items 1 and 3 of the ALS functional rating scale, and visual analog scales for drooling and swallowing function.

RESULTS:

Although both groups exhibited a similar improvement in drooling, Group B had a mild but significant deterioration in bulbar function that was not evident in Group A.

CONCLUSIONS:

These results suggest that BTX-A has a safer profile when reconstituted with 1 ml instead of 2 ml of saline.

PMID:
23281147
DOI:
10.1002/mus.23692
[Indexed for MEDLINE]
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