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Curr Opin Plant Biol. 2013 Feb;16(1):62-9. doi: 10.1016/j.pbi.2012.12.002. Epub 2012 Dec 30.

Molecular mechanisms of robustness in plants.

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1
Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, USA.

Abstract

Robustness, the ability of organisms to buffer phenotypes against perturbations, has drawn renewed interest among developmental biologists and geneticists. A growing body of research supports an important role of robustness in the genotype to phenotype translation, with far-reaching implications for evolutionary processes and disease susceptibility. Similar to animals and fungi, plant robustness is a function of genetic network architecture. Most perturbations are buffered; however, perturbation of network hubs destabilizes many traits. Here, we review recent advances in identifying molecular robustness mechanisms in plants that have been enabled by a combination of classical genetics and population genetics with genome-scale data.

PMID:
23279801
PMCID:
PMC3577948
DOI:
10.1016/j.pbi.2012.12.002
[Indexed for MEDLINE]
Free PMC Article
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