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Oral Dis. 2013 Sep;19(6):620-7. doi: 10.1111/odi.12048. Epub 2012 Dec 27.

Microvessel density and VEGF, HIF-1α expression in primary oral melanoma: correlation with prognosis.

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1
Department of Clinic and Molecular Sciences-Dermatology, Marche Polytechnic University, Ancona, Italy.

Abstract

OBJECTIVE:

To understand the role of angiogenesis and hypoxia in cancer progression of primary oral melanoma (POM).

MATERIALS AND METHODS:

Sixteen malignant primary melanomas were immunostained with markers CD34, VEGF and HIF-1α. Stained cells were counted in the invasive front and inside the tumour, and the differences were compared and correlated with histological parameters and disease-specific survival of the patients.

RESULTS:

Tumour invasive front showed increased MVD and increased vessel VEGF and HIF-1α expression compared with the intratumoural compartment. No such differences were seen in tumoural melanocytes of the two compartments. Positive correlations were observed between CD34 and VEGF, CD34 and HIF-1α and VEGF and HIF-1α expression in invasive front vessels. CD34 expression was statistically correlated with the level of infiltration. A significant trend to worse disease-free survival was also determined with increased invasive front vessel expression of CD34, VEGF and HIF-1α.

CONCLUSIONS:

Our data highlight the importance of the invasive margin in POM biology. The high angiogenic activity and endothelial VEGF and HIF-1α expression in invasive front vessels have a significant impact on patient survival and future agents targeted against VEGF pathway may represent a novel and effective therapeutic opportunity. Larger studies are needed to further address our findings.

KEYWORDS:

HIF-1α; MVD; VEGF; invasive margin; oral melanoma; survival

PMID:
23279259
DOI:
10.1111/odi.12048
[Indexed for MEDLINE]
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