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Genome Integr. 2012 Dec 31;3(1):10. doi: 10.1186/2041-9414-3-10.

Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?

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1
Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA. dale_ramsden@med.unc.edu.

Abstract

The Nonhomologous end joining pathway is essential for efficient repair of chromosome double strand breaks. This pathway consequently plays a key role in cellular resistance to break-inducing exogenous agents, as well as in the developmentally-programmed recombinations that are required for adaptive immunity. Chromosome breaks often have complex or "dirty" end structures that can interfere with the critical ligation step in this pathway; we review here how Nonhomologous end joining resolves such breaks.

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