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Transl Stroke Res. 2012 Sep;3(3):397-407. doi: 10.1007/s12975-012-0194-5. Epub 2012 Jun 22.

Introduction of a rabbit carotid artery model for sonothrombolysis research.

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Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103-8756, USA.


The goal of this study was to develop an in vivo sonothrombolysis model for stroke research. The rabbit carotid artery has average vessel diameters similar to human M1/M2 segments and allows generation of a thrombotic occlusion using various kinds of thrombus material as well as thrombus placement under visual control. It further allows real-time monitoring of flow and clot mechanics during the sonothrombolysis procedure using high-frequency diagnostic ultrasound. In the present study, the model will be introduced and first results to show feasibility using diagnostic as well as high-intensity focused ultrasound will be presented.

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