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J Infect Dis. 2013 Mar 15;207(6):898-902. doi: 10.1093/infdis/jis777. Epub 2012 Dec 28.

Cytomegalovirus DNA in semen and blood is associated with higher levels of proviral HIV DNA.

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1
University of California-San Diego, 9500 Gilman Dr, MC 0679, La Jolla, CA 92093-0679, USA. gianella@ucsd.edu

Abstract

Over three-fourths of human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) have at least one herpesvirus detected in their semen, and cytomegalovirus (CMV) is the most prevalent. The presence of CMV is associated with higher T-cell immune activation and with HIV disease progression in treated and untreated individuals. In this study of 113 antiretroviral (ART)-naive HIV-infected MSM, we found that CMV replication in blood and semen was associated with higher levels of HIV DNA in peripheral blood mononuclear cells. These observations suggest that interventions aimed to reduce CMV replication and, thus, systemic immune activation could decrease the size of the latent HIV reservoir.

PMID:
23275608
PMCID:
PMC3571441
DOI:
10.1093/infdis/jis777
[Indexed for MEDLINE]
Free PMC Article

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