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Mol Biol Rep. 2013 Apr;40(4):3193-6. doi: 10.1007/s11033-012-2394-1. Epub 2012 Dec 30.

Genetic analysis of twelve X-chromosomal STRs in Japanese and Chinese populations.

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  • 1Division of Legal Medicine, Department of Social Medicine, Nihon University School of Medicine, 30-1, Oyaguchi, Kamicho, Itabashi-ku, Tokyo 173-8610, Japan.


We investigated the genetic markers of twelve X-STR loci in 670 healthy, unrelated Japanese (438 men and 232 women) from Tokyo and 488 Chinese (263 men and 225 women) from Shenyang, using the Investigator Argus X-12 kit. Allele and haplotype analyses of twelve X-STRs clustered into four linkage groups indicated that they are highly informative for forensic applications in Japanese and Chinese populations. Hardy-Weinberg equilibrium tests demonstrated no significant deviations in the two populations. Among the four closely linked X-STR trios, some haplotype unique to Japanese or Chinese population were detected. Haplotype diversity for each linkage group ranged from 0.9861 to 0.9968, showing high values in each of the study populations. The genetic distances between populations based on the 12 X-STR loci and the phylogenetic tree revealed long genetic distances between Asian and Caucasian populations and between Asian and African population (Moroccan). These results suggest that the twelve X-STR loci will contribute to forensic casework in Japanese and Chinese populations.

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