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Clin Chim Acta. 2013 Feb 18;417:54-6. doi: 10.1016/j.cca.2012.12.019. Epub 2012 Dec 28.

The distribution of cardiac troponin I in a population of healthy children: lessons for adults.

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  • 1University of Canberra, Canberra, ACT, Australia.

Abstract

OBJECTIVES:

To describe the distribution of hs-cTnI in a large cohort of healthy children.

DESIGN AND METHODS:

As part of the LOOK study, blood was collected from a large cohort of healthy children on 3 separate occasions when the children were aged 8, 10 and 12years. Samples were stored at -80°C after collection and assayed after 1 freeze-thaw cycle using a pre-commercial release hs-cTnI assay from Abbott Diagnostics.

RESULTS:

More than 98% of the 12year-old children had cTnI above the LoD of 1.0ng/L. For the 212 boys the central 95% of results was distributed in a Gaussian fashion. For the 237 girls, the initial analysis was non-Gaussian, but after the elimination of 2 results, the pattern for girls was also Gaussian.

CONCLUSIONS:

In healthy children, cTnI is present in a Gaussian distribution. Even minor illnesses can cause some troponin release, distorting this Gaussian distribution.

PMID:
23274622
DOI:
10.1016/j.cca.2012.12.019
[PubMed - indexed for MEDLINE]
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