Format

Send to

Choose Destination
Epileptic Disord. 2012 Dec;14(4):398-402. doi: 10.1684/epd.2012.0541.

Heterotopic reelin in human nodular heterotopia: a neuropathological study.

Author information

1
Clinical Epileptology and Experimental Neurophysiology Unit, Fondazione IRCCS, Istituto Neurologico C Besta, Milano, Italy.

Abstract

AIM:

The extracellular matrix glycoprotein reelin plays a crucial role in the control of neuronal migration and during development is expressed by Cajal-Retzius cells in the marginal zone. The purpose of this study was to investigate the possible involvement of reelin in the pathogenesis of human nodular heterotopia, a malformation of cortical development frequently associated with focal drug-resistant epilepsy.

METHODS:

Five patients presenting with subcortical nodular heterotopia and referred for epilepsy surgery, after a comprehensive presurgical investigation, were considered. The surgical specimens were studied by combining immunohistochemistry, double immunofluorescence, and in situ hybridisation procedures.

RESULTS:

The selected cases were characterised by the presence of multiple nodules presenting in the core cell-free zones, reminiscent of the cortical molecular layer. In all cases, small reelin-positive cells, without typical Cajal-Retzius cell features, were distributed inside the nodules and localised in these cell body-sparse regions.

CONCLUSION:

The presented data corroborate the hypothesis that reelin might be involved in human heterotopic nodular formation.

PMID:
23274163
DOI:
10.1684/epd.2012.0541
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for John Libbey Eurotext
Loading ...
Support Center