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Bioorg Med Chem Lett. 2013 Feb 1;23(3):641-5. doi: 10.1016/j.bmcl.2012.12.001. Epub 2012 Dec 8.

Synthesis and antioxidant activity of thymol and carvacrol based Schiff bases.

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  • 1Department of Chemistry, University of Delhi, Delhi 110007, India.


Thymol and carvacrol are well known antioxidants found in the extract of the plants of thyme species. The Schiff bases of 2-iso-propyl-5-methyl-phenol (thymol/1a), 2-tert-butyl-5-methyl-phenol (1b) and 5-iso-propyl-2-methyl-phenol (carvacrol/1c) exhibited much better antioxidant activity than thymol and carvacrol in DPPH assay. Ten compounds (4k, 4l, 4r, 5k, 5l, 5q, 5r, 6k, 6l and 6r) showed better or similar activity as compared to the reference compound ascorbic acid. Twenty-four most active compounds were also screened by ABTS method and showed 60-90% inhibition at 5 μg/mL concentration.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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