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Org Lett. 2013 Jan 18;15(2):278-81. doi: 10.1021/ol303400s. Epub 2012 Dec 28.

Copper-catalyzed direct arylation of cyclic enamides using diaryliodonium salts.

Author information

1
Institut de Chimie Organique et Analytique, UMR 7311 CNRS, rue de Chartres, Université d'Orléans, F-45067 Orléans Cedex 2, France.

Abstract

A convenient method for the copper(II)-catalyzed direct arylation of cyclic and nonaromatic enamides using diaryliodonium salts has been developed. The reaction demonstrates large functional group tolerance, good yields, and total regioselectivity with a C(3)-functionalization. The synthetic potential of this coupling was explored by using a range of readily accessible diaryliodonium salts and enamides.

PMID:
23272978
DOI:
10.1021/ol303400s

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