Format

Send to

Choose Destination
Ann Thorac Surg. 2013 Jan;95(1):373-80. doi: 10.1016/j.athoracsur.2012.07.077. Epub 2012 Dec 25.

Preload sensitivity in cardiac assist devices.

Author information

1
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. fukamak@ccf.org

Abstract

With implantable cardiac assist devices increasingly proving their effectiveness as therapeutic options for end-stage heart failure, it is important for clinicians to understand the unique physiology of device-assisted circulation. Preload sensitivity as it relates to cardiac assist devices is derived from the Frank-Starling relationship between human ventricular filling pressures and ventricular stroke volume. In this review, we stratify the preload sensitivity of 17 implantable cardiac assist devices relative to the native heart and discuss the effect of preload sensitivity on left ventricular volume unloading, levels of cardiac support, and the future development of continuous-flow total artificial heart technology.

PMID:
23272869
PMCID:
PMC3592985
DOI:
10.1016/j.athoracsur.2012.07.077
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center